Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer)

PREMM1,2,6 Model: Prediction Model for MLH1, MSH2, and MSH6 Gene Mutations

The PREMM1,2,6 model is a clinical prediction algorithm designed for use by healthcare professionals to estimate the cumulative and individual probabilities that an individual is an MLH1, MSH2, or MSH6 mutation carrier. Mutations in these genes are found in most patients with Lynch syndrome.

Proband Information
(if unknown, estimate)
(if unknown, estimate)


Relatives Information - First Degree
(if unknown, estimate)
(if unknown, estimate)
Relatives Information - Second Degree
(if unknown, estimate)
(if unknown, estimate)

Overall Predicted Probability of MLH1, MSH2, or MSH6 Mutation:

Predicted Probability of MLH1 Mutation:

Predicted Probability of MSH2 Mutation:

Predicted Probability of MSH6 Mutation:

If the overall predicted probability is ≥ 5%, referral for genetic evaluation and/or molecular testing of tumor sample for microsatellite instability (MSI) or immunohistochemistry (IHC) testing should be considered. When a tumor sample is not readily available, germline sequencing should be considered in patients with ≥ 5% risk (National Comprehensive Cancer Network [NCCN] Guidelines Version 2.2012, Colorectal Cancer Screening).