Overall Predicted Probability of MLH1, MSH2, or MSH6 Mutation:
Predicted Probability of MLH1 Mutation:
Predicted Probability of MSH2 Mutation:
Predicted Probability of MSH6 Mutation:
If the overall predicted probability is ≥ 5%, referral for genetic evaluation and/or molecular testing of tumor sample for microsatellite instability (MSI) or immunohistochemistry (IHC) testing should be considered. When a tumor sample is not readily available, germline sequencing should be considered in patients with ≥ 5% risk (National Comprehensive Cancer Network [NCCN] Guidelines Version 2.2012, Colorectal Cancer Screening).